3/11/2023 0 Comments How to prepare 10 nitric acidThe anti-inflammatory activity of these dendrimers was evaluated, showing that the bifunctional dendrimers have an inverse correlation between concentration and anti-inflammatory activity, with an effect dramatically pronounced for Dendri-(NO/UDCA) 54 20, which at just 0.25 nM inhibited 76.1% of IL-8 secretion. For comparison, a lower-generation dendrimer bearing 18 NO-releasing groups and 18 UDCA units (Dendri-(NO/UDCA) 18) was also synthesized. Herein, we describe the synthesis of a well-defined bifunctional dendrimer with 108 termini bearing 54 NO-releasing groups and 54 UDCA units (Dendri-(NO/UDCA) 54). Since inflammatory processes are present in the mechanisms of many diseases, these molecules are important for the development of new drugs. Nitric oxide (NO) and ursodeoxycholic acid (UDCA) are endogenous molecules involved in physiological processes associated with inflammation.
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